P. aeruginosa , a common cause of nosocomial urinary tract infections (UTI’s), represents 7% of nosocomially-acquired UTIs in North America and Europe These infections are associated with an indwelling catheter , instrumentation of the urinary system, chronic prostatitis , nephrolithiasis, as well as prior antibiotic therapy. Community-acquired UTI’s are rarely caused by P. aeruginosa ( 97 ). In those persons with a neurogenic bladder, or in children with frequent infection from vesicoureteral reflux (VUR), P. aeruginosa UTI infection may occur. P. aeruginosa should be suspected in break-through infections in the urinary tract, especially in a host recently and/ or currently receiving antimicrobial agents, due to its nature to be resistant to many common antibiotics. In the elderly, urosepsis from P. aeruginosa may also follow acquisition of a simple UTI. Treatment regimens depend upon the presence of structural abnormalities or indwelling catheter(s), evidence of systemic sepsis , as well as the site of involvement, and prior antibiotic use. Eradication of the organism remains challenging and requires elimination of the predisposing factors in addition to antibiotic therapy.
Modeling host-pathogen interactions for Pto DC3000 with Gene Ontology Annotation
To receive email updates about this page, enter your email address:
"Research in the area of NTM lung disease has been woefully underfunded with no major therapeutic advances in the last 20 years. The availability of a once-a-day product that can help reduce bacterial density in these patients would represent a major step forward in the treatment of this disease," added Dr. Griffith.
Guss J, Ruckenstein MJ. Infections of the external ear. In: Cummings CW, Flint PW, Haughey BH, et al, eds. Otolaryngology: Head & Neck Surgery. 5th ed. Philadelphia, Pa: Mosby Elsevier; 2010:chap 137.